ERP-Lab 台大醫院精神部 神經生理研究室

ERP, MMN, P50, schizophrenia, prodrome, MEG


P50與MMN到底有沒有關係?

支持P50與MMN有關係之文獻研究:

Gjini, K., Arfken, C., Boutros, N.N., 2010. Relationships between sensory “gating out” and sensory “gating in” of auditory evoked potentials in schizophrenia: a pilot study. Schizophr. Res. 121, 139-145.【注意這一篇:Boutrous不知是否為了讓他的研究有道理,提出了奇特的gating in[MMN]–gating out[P50/N100/P200]說法】When including all subjects (N=24) a negative correlation was found between the P50 gating and the amplitude of the MMN. In healthy subjects this correlation was significantly stronger compared to schizophrenia patients. (繼續閱讀…)

P50與N100

Test–retest reliability was moderate to high for P50, N100, and P200 latencies, amplitudes, and difference scores, low to moderate for N100 and P200 gating ratios, but low for P50 ratio ( [Rentzsch et al., 2008] and [Fuerst et al., 2007]).

Evidence of abnormalities in mid-latency auditory evoked responses (MLAER) in cognitive subtypes of patients with schizophrenia 澳洲Assen Jablensky團隊 2011刊登於Psychiatry Research之文章: abnormal pathophysiologic mechanisms (P50/N100/P200) underlying the electrophysiological brain responses to auditory stimulation are associated with the pervasive cognitive deficits, which characterize the pervasive cognitive deficits of schizophrenia

Cognitive abilities and 50- and 100-msec paired-click processes in schizophrenia.Smith AK, Edgar JC, Huang M, Lu BY, Thoma RJ, Hanlon FM, McHaffie G, Jones AP, Paz RD, Miller GA, Cañive JM.Am J Psychiatry. 2010 Oct;167(10):1264-75. 這一篇不但作了P50/N100也作了M50/M100

一些與ERP有關的Wiki

SCCN的EEGLAB wiki當然是最重要的了!

Mass Univariate ERP Toolbox (David Groppe)【與EEGLAB、ERPLAB均相容】

在英國的MRC-CBU之MEG Lab:他們用Elekta machine:http://imaging.mrc-cbu.cam.ac.uk/meg/maxpreproc

Neural ElectroMagnetic Ontologies (NEMO) is an NIH funded project that aims to create EEG and MEG ontologies and ontology based tools

http://nemo.nic.uoregon.edu/wiki/NEMO

NEMO ERP Analysis Toolkit

COGS研究團隊的ERP文章

Inhibition of the P50 cerebral evoked response to repeated auditory stimuli: results from the Consortium on Genetics of Schizophrenia.      Schizophr Res. 2010 Jun;119(1-3):175-82. Epub 2010 Apr 10.

 

NIHMS259208.html請注意:不是用ERP記錄系統記錄P50,而是『Vertex貼一根,耳朵貼一根,眼睛旁邊貼兩根』(LEA2003, RaveWave Systems, Aurora, CO). Electrophysiological recording  EEG recordings were made from the vertex referenced to the left ear lobe. Electro-oculographic activitywas recorded between the lateral canthus and superior orbit of the right eye.

ERP的SOP來了!

這一篇剛剛出版的刊登在 Current Protocols in Neuroscience 6.25.11, July 2010上之Electroencephalography (EEG) and Event-Related Potentials (ERPs) with Human Participants ,是UCSD的Gregory A. Light (繼續閱讀…)

M50/M100: 用MEG做P50/N100

New Mexican研究團隊,對於M50特別有研究心得

Lateralized abnormalities in auditory M50 sensory gating and cortical thickness of the superior temporal gyrus in post-traumatic stress disorder: Preliminary results Original Research Article
Psychiatry Research: Neuroimaging, In Press, Corrected Proof, Available online 6 January 2011
Michael Hunter, Gerardo Villarreal, Greg R. McHaffie, Billy Jimenez, Ashley K. Smith, Lawrence A. Calais, Faith Hanlon, Robert J. Thoma, José M. Cañive

因為MEGnovel technology,非常罕見稀有(就像靈長類研究,作一兩隻猴子也可以發表),所以下面這一篇MEG作不出P50也可以發表在Schizophrenia Research (繼續閱讀…)

P50 vs. Antipsychotics

圖1 (繼續閱讀…)

P50與symptom dimension!

2005年,一群法國人發現比起PANSS負性總分低的55位schizophrenia patients,PANSS負性總分高的31位schizophrenia patients具有significantly increased T/C ratios[P50 inhibitory gating deficit is correlated with the negative symptomatology of schizophrenia. Psychiatry Research. 136 27-34]

不過同年New Mexico研究團隊(MXHuang, Michael Weisand)同時做ERP(P50)與MEG(M50),最後發現Negative symptom與P50無關,但卻與M50有相關      M50 sensory gating predicts negative symptoms in schizophrenia. Schizophrenia Research 2005 Mar 1;73(2-3):311-8.

一樣是用MEG:這一篇1998年[Resersal of cerebral asymmetry  in schizophrenia  measured with magnetoencephalography]認為reversed left-right asymmelry與PANSS general psychopathological score有相關

P50 的anatomy

雖然以往的動物與人類手術研究認為auditory cortex, prefrontal cortex and hippocampus in mediating the sensory gating response,這一篇由新墨西哥州Mind Research Network的作品The neural networks underlying auditory sensory gating. Neural Image 2009 44(1)2009, Pages 182-189使用 fMRI認為P50

  1. gating response for both paired-tone conditions was primarily mediated by auditory and prefrontal cortex, with potential contributions from the thalamus (繼續閱讀…)

P50的影響因素:age? 性別?教育程度?抽煙?

圖1
Age是否影響P50? (繼續閱讀…)

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