ERP-Lab 台大醫院精神部 神經生理研究室

ERP, MMN, P50, schizophrenia, prodrome, MEG

Clonidine可以改善 P50

Clonidine Normalizes Levels of P50 Gating in Patients With Schizophrenia  on Stable Medication

 Bob Oranje and Birte Y. Glenthøj    Schizophr Bull 2014 40: 1022-1029

Supplementary material is available at http://schizophren



A statistical methodology to improve accuracy in differentiating schizophrenia patients from healthy controls    Psychiatry Research 21 February-27 February 2014

Rosalind M. Peters, Klevest Gjini, Thomas N. Templin, Nash N. Boutros



用ERP預測attention task結果

UCHSC的Ann Olnicy 研究團隊於Schizophrenia Research 2013, 147(1) Pages 196–200的新作

Early sensory processing deficits predict sensitivity to distraction in schizophrenia
Full-size image (20 K)



Differential relationships of impulsivity or antisocial symptoms on P50, N100, or P200 auditory sensory gating in controls and antisocial personality disorder

Lijffijt的UTexas團隊刊登於Journal of Psychiatric Research 2012; 46(6)Pages 743–750的文章 (繼續閱讀…)

Gating out vs. Gating in

Sensory gating-out and gating-in in normal and schizophrenic participants.

Nash N Boutros研究團隊於2012年出版在Clinical EEG  Neuroscience的文章


S1 vs. S2對於 Sensory Gating之貢獻

Probing the relative contribution of the first and second responses to sensory gating indices: a meta-analysis.

Nash N Boutros研究團隊於2011年出版在Psychophysiology 的文章 (繼續閱讀…)

P50 是State Marker?還是Trait Marker?

認為P50是trait marker的文章非常多:在慢性病患、未用藥的病患、初次發作的病患、未發病的一級親屬、分裂病性人格疾患者身上,都可以發現P50 suppression之缺損。這些缺損型態相似,而且各組之差異不大,顯示P50 suppression異常可能來自於共同的遺傳因素,是一種trait marker

  1. Sensory Gating Deficits Assessed by the P50 Event-Related Potential in Subjects With Schizotypal Personality Disorder.Kristin S. Cadenhead, M.D.; Gregory A. Light, B.A.; Mark A. Geyer, Ph.D.; David L. Braff, M.D.
  2. Coon H, Plaetke R, Holik J, et al.: Use of a neurophysiological trait in linkage analysis of schizophrenia. Biol Psychiatry 1993;34:277-289.
  3. (事實上:Endophenotype的 定義本身: 就是符合Trait Marker啦)

Auditory P50 between smokers and non-smokers among drug-naive first episode schizophrenic patients

Differential sensory gating functions between smokers and non-smokers among drug-naive first episode schizophrenic patients   Psychiatry Research 2011, Vol. 188, Iss. 3, Pages 327-333 
這篇是上海交通大學與NYU的聯合研究  (繼續閱讀…)

Potential neural generators of P50

下面這篇Psychophysiology 2010,是UCLA的CINDY  YEE團隊:針對STG, hippocampus, DLPFC, and thalamus四個區域所進行的研究

Distinct neural generators of sensory gating in schizophrenia

一樣是STG, hippocampus, DLPFC, and thalamus四個區域所進行的研究:Robert Freedman的團隊在Increased hemodynamic response in the hippocampus, thalamus and prefrontal cortex during abnormal sensory gating in schizophrenia(2007 Schizophrenia Research)發現

Compared to healthy comparison subjects, patients with schizophrenia exhibited greater activation in the hippocampus, thalamus, and dorsolateral prefrontal cortex (DLPFC) during the fMRI sensory gating task. No group difference was observed in the superior temporal gyrus.

不過,下面這一篇New Mexican 團隊The neural networks underlying auditory sensory gating(2008 NeuroImage):則發現there was no evidence of hippocampal involvement

The problem/downside of P50

雖然自 1997. Linkage of a neurophysiological deficit in schizophrenia to a chromosome 15 locus. PNAS.這一篇推波助瀾後,Robert Freedman跟Ann Olincy等人鼓吹之下目前有相當多的P50研究,但是P50的確有許多問題:

  1. P50之SNR太小,許多人均建議amplitude有下限之規範 (繼續閱讀…)

total of 2101331 visits