ERP-Lab 台大醫院精神部 神經生理研究室

ERP, MMN, P50, schizophrenia, prodrome, MEG


A statistical methodology to improve accuracy in differentiating schizophrenia patients from healthy controls    Psychiatry Research 21 February-27 February 2014

Rosalind M. Peters, Klevest Gjini, Thomas N. Templin, Nash N. Boutros




Test–retest reliability was moderate to high for P50, N100, and P200 latencies, amplitudes, and difference scores, low to moderate for N100 and P200 gating ratios, but low for P50 ratio ( [Rentzsch et al., 2008] and [Fuerst et al., 2007]).

Evidence of abnormalities in mid-latency auditory evoked responses (MLAER) in cognitive subtypes of patients with schizophrenia 澳洲Assen Jablensky團隊 2011刊登於Psychiatry Research之文章: abnormal pathophysiologic mechanisms (P50/N100/P200) underlying the electrophysiological brain responses to auditory stimulation are associated with the pervasive cognitive deficits, which characterize the pervasive cognitive deficits of schizophrenia

Cognitive abilities and 50- and 100-msec paired-click processes in schizophrenia.Smith AK, Edgar JC, Huang M, Lu BY, Thoma RJ, Hanlon FM, McHaffie G, Jones AP, Paz RD, Miller GA, Cañive JM.Am J Psychiatry. 2010 Oct;167(10):1264-75. 這一篇不但作了P50/N100也作了M50/M100



Sensory-gating deficit of the N100 mid-latency auditory evoked potential in medicated schizophrenia patients  Original Research Article
Schizophrenia Research, Volume 113, Issues 2-3, September 2009, Pages 339-346: Nash N. Boutros, Anke Brockhaus-Dumke, Klevest Gjini, Andrei Vedeniapin, Mohamad Elfakhani, Scott Burroughs, Matcheri Keshavan


  1. Better gating measures than P50 (Boutros et al. 2004) [Brockhaus-Dumke A,(2008)Schizophr Res. 99:238-249.[242頁表table 3]
  2. N1 reductions specific to schizophrenia may be due to deficits in the primary auditory cortex or NMDA neurotransmitter systems (Javitt et al. 2000) (繼續閱讀…)


雖然大部分文獻都認為P200已經受到attention影響,但是下面這兩篇Boutros研究團隊作品,則使用同樣的pair-clicks測量P50/N100/P200 (繼續閱讀…)

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