ERP-Lab 台大醫院精神部 神經生理研究室

ERP, MMN, P50, schizophrenia, prodrome, MEG

Reduced mismatch negativity and increased variability of brain activity in schizophrenia

德國研究團隊之文章 Reduced mismatch negativity and increased variability of brain activity in schizophrenia   Original Research Article
Clinical Neurophysiology, In Press, Corrected Proof, Available online 26 May 2011 (繼續閱讀…)


這是心心水滴的版主級大腕:所發表於Cognitive Neurodynamics的文章

Answering Six Questions in Extracting Children’s Mismatch Negativity through Combining WaveletDecomposition and Independent Component Analysis,Cognitive Neurodynamics, DOI: 10.1007/s11571-011-9161-1, 2011

This study combines wavelet decomposition and independent component analysis (ICA) to extract mismatch negativity (MMN) from electroencephalography (EEG) recordings. As MMN is a small event-related potential (ERP), a systematic ICA based approach is designed, exploiting MMN’s temporal, frequency and spatial information. (繼續閱讀…)

Gamma ASSR

  1. 必看:由哈佛大學的Spencer, Salisbury, Shenton, McCarley研究團隊寫的γ-Band Auditory Steady-State Responses Are Impaired in First Episode Psychosis Biological Psychiatry 2008; 64(5)
  2. 日本研究團隊用MEG作的Reduced high and low frequency gamma synchronization in patients with chronic schizophrenia
    Schizophrenia Research, In Press, Corrected Proof, Available online 16 August 2011 . The main findings were: (繼續閱讀…)

UCSD的Greg Light研究團隊之新作

Automatic sensory information processing abnormalities across the illness course of schizophreniaPsychol Med. 2011 Jul 11:1-13

Jahshan C, Cadenhead KS, Rissling AJ, Kirihara K, Braff DL, Light GA.

背景介紹:印度人Jahshan長期擔任UCSD的Kristin Cadenhead的研究助理,進行prodrome之ERP收案。本篇是由她在SDSU(San Diego State University)拿到PhD之論文改寫 (繼續閱讀…)

MMN與duration of illness (close to illness onset)

whether “MMN deficits are present at illness onset” remains controversial

  1. Salisbury團隊,在2002年發現 normal frequency MMN generation in first-episode patients: Salisbury DF, Shenton ME, Griggs CB, Bonner-Jackson A, McCarley RW(2002): Mismatch negativity in chronic schizophrenia and first-episode schizophrenia. Arch Gen Psychiatry 59:686–694.但是,longitudinal追蹤1.5年後,就有差別了[mismatch negativity and Heschl’s gyrus volume in first episode schizophrenia, kasai, salisbury et al. Schizophrenia Research 未正式出版]
  2. deficient MMN generation in patients who were within 1.5 years of their first episode: Javitt DC, Shelley AM, Silipo G, Lieberman JA (2000): Deficits in auditory and visual context-dependent processing in schizophrenia: Defining the pattern. Arch Gen Psychiatry 57:1131–1137.


auditory MMN vs.N2b


MMN/P3a in obstructive sleep apnea syndrome(OSAS)

Gosselin, N., A. Mathieu, et al. (2006). “Deficits in involuntary attention switching in obstructive sleep apnea syndrome.” Neuroscience Letters 408(1): 73-78.

[Subjects and Methods]13  OSAS patients and 13 age-matched controls,注意本篇之parameter setting: 

Paradigm setting – Auditory Oddball Paradigm presented by inserted earphones

–          Task: Subjects were asked to ignore the sounds & to read during the recording

–          Stimulus:  standard (95%, 1000Hz pure tone), high deviant (2.5%, 1250Hz) and low deviant (2.5%, 1050Hz) tone



Gjini, K., Arfken, C., Boutros, N.N., 2010. Relationships between sensory “gating out” and sensory “gating in” of auditory evoked potentials in schizophrenia: a pilot study. Schizophr. Res. 121, 139-145.【注意這一篇:Boutrous不知是否為了讓他的研究有道理,提出了奇特的gating in[MMN]–gating out[P50/N100/P200]說法】When including all subjects (N=24) a negative correlation was found between the P50 gating and the amplitude of the MMN. In healthy subjects this correlation was significantly stronger compared to schizophrenia patients. (繼續閱讀…)

MMN: Frequency deviant vs. Duration deviant

本研究室自2009年2月28日起嘗試試用MMN2 paradigm (Both Duration and Frequency MMN are acquired in the same session)      自2010年3月1日起恢復duration MMN paradigm(但兒童個案仍用MMN2 paradigm)

1257~1333; 3261~3335

以下各篇都是同一個研究有做Frequency deviant vs. Duration deviant

  1. MMN responsivity to manipulations of frequency and duration deviants in chronic, clozapine-treated schizophrenia patients Schizophrenia Research, 2010 126(3) Jemeen Horton, Anne Millar, Alain Labelle, Verner J. Knott [Peak latency and amplitude derived from Fz, the site of maximum MMN amplitude]
  2. (繼續閱讀…)

Prediction of Psychosis by Mismatch Negativity

Anke Brockhaus-Dumke研究團隊於Biological Psychiatry的新文章Prediction of Psychosis by Mismatch Negativity    (繼續閱讀…)

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