ERP-Lab 台大醫院精神部 神經生理研究室

ERP, MMN, P50, schizophrenia, prodrome, MEG


P300的ERSP與ITC

Exploring the dynamics of P300 amplitude in patients with schizophrenia 刊登於International Journal of Psychophysiology  September 2011, 81(3) 159–168葡萄牙研究團隊之文章

This study investigated the time-frequency dynamics of P300 generation in patients with first-onset schizophrenia.

A group of 40 patients with first-onset schizophrenia and 40 controls performed an auditory oddball task. Wavelet analysis of the single-trial data was used to compute the Event-Related Spectral Perturbation (ERSP) and the Inter-Trial Phase Coherence (ITC) for the deltathetaalphabeta and gamma bands on the 50 ms window around peak P300 amplitude. The contribution of power and synchrony for P300 amplitudes was studied through correlation and regression analysis. Further, two sub-samples in which patients had lower or higher P300 amplitudes than their control match were contrasted. (繼續閱讀…)

Ultra-High-Risk vs. Schizophrenia Subjects之MMN

看看這一篇韓國Jun Soo Kwon研究團隊2012出版在Schizophrenia Bulletin 38(6)1258-1267的Aberrant Auditory Processing in Schizophrenia and in Subjects at Ultra-High-Risk for Psychosis

  1. This study evaluated the sensitivity of MEG N1m, N1m adaptation, and magnetic counterpart of MMN (MMNm) in 16 UHR subjects, 15 schizophrenia patients, and 18 healthy controls (HCs) during a passive auditory oddball task.
  2. 只有Deficits in auditory sensory memory[MMNm], similarly impaired in both (Ultra-High-Risk vs. Schizophrenia) groups. 而MEG N1m, N1m adaptation則在兩組間,有所差別

再看2012年Biological Psychiatry; 71(2),對於當期下面的一篇澳洲研究團隊大作之評論In Search of Psychosis Biomarkers in High-risk Populations: Is the Mismatch Negativity the One We’ve Been Waiting for? (繼續閱讀…)

Gamma ASSR

  1. 必看:由哈佛大學的Spencer, Salisbury, Shenton, McCarley研究團隊寫的γ-Band Auditory Steady-State Responses Are Impaired in First Episode Psychosis Biological Psychiatry 2008; 64(5)
  2. 日本研究團隊用MEG作的Reduced high and low frequency gamma synchronization in patients with chronic schizophrenia
    Schizophrenia Research, In Press, Corrected Proof, Available online 16 August 2011 . The main findings were: (繼續閱讀…)

MMN與duration of illness (close to illness onset)

whether “MMN deficits are present at illness onset" remains controversial

  1. Salisbury團隊,在2002年發現 normal frequency MMN generation in first-episode patients: Salisbury DF, Shenton ME, Griggs CB, Bonner-Jackson A, McCarley RW(2002): Mismatch negativity in chronic schizophrenia and first-episode schizophrenia. Arch Gen Psychiatry 59:686–694.但是,longitudinal追蹤1.5年後,就有差別了[mismatch negativity and Heschl’s gyrus volume in first episode schizophrenia, kasai, salisbury et al. Schizophrenia Research 未正式出版]
  2. deficient MMN generation in patients who were within 1.5 years of their first episode: Javitt DC, Shelley AM, Silipo G, Lieberman JA (2000): Deficits in auditory and visual context-dependent processing in schizophrenia: Defining the pattern. Arch Gen Psychiatry 57:1131–1137.

 

FEP的mismatch negativity

Salisbury團隊,在2002年發現 normal frequency MMN generation in first-episode patients: Salisbury DF, Shenton ME, Griggs CB, Bonner-Jackson A, McCarley RW(2002): Mismatch negativity in chronic schizophrenia and first-episode schizophrenia. Arch Gen Psychiatry 59:686–694.

Michie團隊,在2010年的海報MISMATCH NEGATIVITY TO DURATION DEVIANTS IN FIRST EPISODE PSYCHOSIS AND IN THE PRODROME

Umbricht與Javitt這篇Electrophysiological Indices of Automatic and Controlled Auditory Information Processing in First-Episode, Recent-Onset and Chronic Schizophrenia[Biological Psychatry 2006;29(8)762-772]作的是mismatch negativity; N2; P3,重要結論如下:

  1. Recent-onset and chronic, but not first-episode patients showed reduced MMN
  2. 與教育程度有關?among first-episode patients: those with low premorbid educational achievement demonstrated significantly reduced MMN

不妨再看一下這一篇:Impaired MMN/P3a complex in first-episode psychosis: Cognitive and psychosocial associations. 澳洲Hermens團隊,刊登於Progress in Neuro-Psychopharmacology and Biological Psychiatry 2010:要點如下 (繼續閱讀…)

First episode schizophrenia的anatomy

為何要做FEP(First Episode Psychosis)的研究呢?因為DUP(duration of untreated psychosis)會造成腦部的改變:因此近年來精神分裂症研究,越來越多人在做FEP(First Episode Psychosis)研究,這樣就避開了長時間的疾病導致腦結構改變的爭議了

(繼續閱讀…)


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