ERP-Lab 台大醫院精神部 神經生理研究室

ERP, MMN, P50, schizophrenia, prodrome, MEG

ARMS與functional connectivity

由莊明哲教授領銜的美國NAPLS Consortium研究團隊於2012年出版在Schizophrenia Research 134(1)1~9的Altered age-related trajectories of amygdala-prefrontal circuitry in adolescents at clinical high risk for psychosis: A preliminary study

  1. Cross-Section研究:Participants (n = 34) performed an emotion processing fMRI task, including emotion labeling, emotion matching, and non-emotional control conditions.
  2. These results suggest that the at-risk syndrome is marked by abnormal development and functional connectivity of neural systems subserving emotion regulation.


英國研究團隊於2012年January出版在Schizophrenia Research; 134(1)Pages 42–48的Reduced mismatch negativity predates the onset of psychosis

  1. 41 cases meeting PACE criteria for the At Risk Mental State (ARMS) and 50 controls performed a duration-deviant MMN. The amplitude of the MMN wave was compared between groups using linear regression. The ARMS subjects were then followed for 2 years to determine their clinical outcome.
  2. The MMN amplitude was significantly reduced in the ARMS group compared to controls. (繼續閱讀…)

Ultra-High-Risk vs. Schizophrenia Subjects之MMN

看看這一篇韓國Jun Soo Kwon研究團隊2012出版在Schizophrenia Bulletin 38(6)1258-1267的Aberrant Auditory Processing in Schizophrenia and in Subjects at Ultra-High-Risk for Psychosis

  1. This study evaluated the sensitivity of MEG N1m, N1m adaptation, and magnetic counterpart of MMN (MMNm) in 16 UHR subjects, 15 schizophrenia patients, and 18 healthy controls (HCs) during a passive auditory oddball task.
  2. 只有Deficits in auditory sensory memory[MMNm], similarly impaired in both (Ultra-High-Risk vs. Schizophrenia) groups. 而MEG N1m, N1m adaptation則在兩組間,有所差別

再看2012年Biological Psychiatry; 71(2),對於當期下面的一篇澳洲研究團隊大作之評論In Search of Psychosis Biomarkers in High-risk Populations: Is the Mismatch Negativity the One We’ve Been Waiting for? (繼續閱讀…)

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