ERP-Lab 台大醫院精神部 神經生理研究室

ERP, MMN, P50, schizophrenia, prodrome, MEG

大麻與Gamma ASSR

Δ(9)-THC Disrupts Gamma (γ)-Band Neural Oscillations in Humans.

Daniel Mathalon 與Judith Ford研究團隊2015刊登於Neuropsychopharmacology( Official publication of the American College of Neuropsychopharmacology (Impact Factor: 8.68).)的文章

Gamma (γ)-band oscillations play a key role in perception, associative learning, and conscious awareness and have been shown to be disrupted by cannabinoids in animal studies. The goal of this study was to determine whether cannabinoids disrupt γ oscillations in humans and whether these effects relate to their psychosis-relevant behavioral effects. The acute, dose-related effects of delta-9-tetrahydrocannabinol (Δ(9)-THC) on the auditory steady-state response (ASSR) were studied in humans (n=20) who completed three test days during which they received intravenous Δ(9)-THC (placebo, 0.015 and 0.03 mg/kg) in a double-blind, randomized, cross-over, and counterbalanced design. Electroencephalography (EEG) was recorded while subjects listened to auditory click trains presented at 20, 30 and 40 Hz. Psychosis-relevant effects were measured with the Positive and Negative Syndrome scale (PANSS). (繼續閱讀…)

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