ERP-Lab 台大醫院精神部 神經生理研究室

ERP, MMN, P50, schizophrenia, prodrome, MEG

大麻與Gamma ASSR

Δ(9)-THC Disrupts Gamma (γ)-Band Neural Oscillations in Humans.

Daniel Mathalon 與Judith Ford研究團隊2015刊登於Neuropsychopharmacology( Official publication of the American College of Neuropsychopharmacology (Impact Factor: 8.68).)的文章

Gamma (γ)-band oscillations play a key role in perception, associative learning, and conscious awareness and have been shown to be disrupted by cannabinoids in animal studies. The goal of this study was to determine whether cannabinoids disrupt γ oscillations in humans and whether these effects relate to their psychosis-relevant behavioral effects. The acute, dose-related effects of delta-9-tetrahydrocannabinol (Δ(9)-THC) on the auditory steady-state response (ASSR) were studied in humans (n=20) who completed three test days during which they received intravenous Δ(9)-THC (placebo, 0.015 and 0.03 mg/kg) in a double-blind, randomized, cross-over, and counterbalanced design. Electroencephalography (EEG) was recorded while subjects listened to auditory click trains presented at 20, 30 and 40 Hz. Psychosis-relevant effects were measured with the Positive and Negative Syndrome scale (PANSS). Read the rest of this entry »


Impairments of event-related magnetic fields in schizophrenia patients with predominant negative symptoms.

Yefet K, Goldstein A, Rabany L, Levkovitz Y.

Psychiatry Res. 2015 Jan 23. pii: S0925-4927(15)00028-1. doi: 10.1016/j.pscychresns.2015.01.016. PMID: 25680554

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東京大學 笠井清登Kiyoto Kasai研究團隊的NIRS文章

Front Psychiatry. 2013 Nov 14;4:145. doi: 10.3389/fpsyt.2013.00145. eCollection 2013.
Near-infrared spectroscopy in schizophrenia: a possible biomarker for predicting clinical outcome and treatment response.








2015的Gamma Activity新文章:Spontaneous Gamma Activity in Schizophrenia

January 14, 2015於JAMA Psychiatry上線的新文章Spontaneous Gamma Activity in Schizophrenia,作者群是 Yoji Hirano; Naoya Oribe等日本團隊,但是指導者是 Kevin M. Spencer  24個控制組與24個思覺失調組進行ASSR

This cross-sectional study reports an increase in spontaneous EEG gamma activity during auditory steady-state stimulation in schizophrenia, reflecting a disruption in the normal balance of excitation and inhibition.

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提到MMN,大家必然想到 discovered in 1978 by 芬蘭籍Risto Näätänen,但如果侷限於美國學者,Daniel C. Javitt 是美國MMN第一把交椅。

P50呢? 擔任過  Am J Psychiatry 總編輯的  Robert Freedman,  是全球P50 第一把交椅。

可想而知:美國的MMN大老與P50大老聯合撰寫之Review 有多麼值得一讀: 如果今年你只想看一篇ERP的文章,就看這一篇吧^_^

Sensory Processing Dysfunction in the Personal Experience and Neuronal Machinery of Schizophrenia   Am J Psychiatry 172:1, January 2015

螢幕快照 2015-01-07 下午6.42.15




















Sensory processing deficits, first investigated by Kraepelin and Bleuler as possible pathophysiological mechanisms in schizophrenia, are now being recharacterized in the context of our current understanding of the molecular and neuro- biological brain mechanisms involved. The National Institute of Mental Health Research Domain Criteria position these deficits as intermediaries between molecular and cellular mechanisms and clinical symptoms of schizophrenia, such as hallucinations. The prepulse inhibition of startle responses by a weaker preceding tone, the inhibitory gating of re- sponse to paired sensory stimuli characterized using the auditory P50 evoked response, and the detection of slight deviations in patterns of sensory stimulation eliciting the cortical mismatch negativity potential demonstrate deficits in early sensory processing mechanisms, whose molecular and neurobiological bases are increasingly well understood. Deficits in sensory processing underlie more complex cog- nitive dysfunction and are in turn affected by higher-level cognitive difficulties. These deficits are now being used to identify genes involved in familial transmission of schizo- phrenia and to monitor potentially therapeutic drug effects for both treatment and prevention. This research also pro- vides a clinical reminder that patients’ sensory perception of the surrounding world, even during treatment sessions, may differ considerably from others’ perceptions. A person’s ability to understand and interact effectively with the sur- rounding world ultimately depends on an underlying sensory experience of it.

Clonidine可以改善 P50

Clonidine Normalizes Levels of P50 Gating in Patients With Schizophrenia  on Stable Medication

 Bob Oranje and Birte Y. Glenthøj    Schizophr Bull 2014 40: 1022-1029

Supplementary material is available at http://schizophren

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P50/N1/P3 amplitudes as classifiers的機器學習machine learning

Critical Evaluation of Auditory Event-Related Potential Deficits in Schizophrenia: Evidence From Large-Scale Single-Subject Pattern Classification 柏林研究團隊刊登於  Schizophrenia Bulletin vol. 40 no. 5 pp. 1062–1071, 2014之文章

144 vs.144

螢幕快照 2015-01-07 下午6.05.29

































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Psychosis Prediction與 Parietal P300

Psychosis Prediction: Stratification of Risk Estimation With Information-Processing and Premorbid Functioning Variables 刊登於Schizophrenia Bulletin vol. 40 no. 6 pp. 1482–1490, 2014的荷蘭研究團隊之文章

螢幕快照 2015-01-07 下午5.34.14








61個個案追蹤36個月後,有18 個個案Transition

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In search of biomarkers in psychiatry: EEG-based measures of brain function

由SCCN的EEGLAB大老Scott Makeig,與精神醫學界泰斗莊明哲院士共同合作,2014年撰寫於遺傳學知名期刊American Journal of Medical Genetics Part B: Neuropsychiatric Genetics(Impact Factor: 3.231 莊教授自己就是主編)的文章

Keywords: EEG; ICA; psychiatry; genetics; ERP

螢幕快照 2014-12-25 上午8.51.49

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EEG Biomarkers of Psychosis, Present and Future

UCSD的EEG/ERP expert Gregory A.Light與SCCN的大老 Scott Makeig,針對在Biological Psychiatry 刊登的B-SNIP文章”Ethridge LE, Hamm JP, Pearlson GD, Tamminga CA, Sweeney JA, Keshavan MS,Brett A. Clementz(2015): Event related potential and time-frequency endophenotypes for schizophrenia and psychotic bipolar disorder. ”

於同期Biological Psychiatry所進行之Commentary:  EEG Biomarkers of Psychosis, Present and Future Read the rest of this entry »

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