ERP-Lab 台大醫院精神部 神經生理研究室

ERP, MMN, P50, schizophrenia, prodrome, MEG

MMN 2015: 7th MMN conference

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 Error Signals from the Brain – 7th Mismatch Negativity Conference (MMN 2015) will be held at the University of Leipzig, Germany, between September 8th and September 11th 2015.

The MMN is an error-signal of the brain that is elicited when an auditory (visual, somato-sensory) stimulus does not match a detected regularity of the sensory environment. It has been used in thousands of experiments in basic and applied (clinical) research to study the brain’s (automatic) encoding and representation of regularities and the detection of respective regularity violations. Therefore the MMN can be regarded as the most influential error signal in cognitive neuroscience. 

The 7th Mismatch Negativity Conference presents the state of the art in methods, theory and application (basic and clinical research) of the MMN. However, it will also cover other error signals of the brain. Moreover, there will be a Hands-on pre-conference workshop devoted to the design of MMN studies and the analysis and interpretation of MMN data as well as a pre-conference workshop on the visual MMN.  Read the rest of this entry »

真會有預測藥物療效的biomarker嗎?

The Promise of Biological Markers for Treatment Response in First-Episode Psychosis: A Systematic ReviewSchizophr Bull (2015)

A rest-activity biomarker to predict response to SSRIs in major depressive disorder. Journal of Psychiatry Research 2015;64

A machine learning approach using EEG data to predict response to SSRI treatment for major depressive disorder.Clinical Neurophysiology 2013 Oct;124(10):1975-85. Read the rest of this entry »

4種MMN均與症狀無關

Judith Ford與Daniel Mathalon研究團隊2015於Biological Psychology的文章Equivalent mismatch negativity deficits across deviant types in early illness schizophrenia-spectrum patients

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從一針見血談起

一針見血早期診斷自閉症  Blood-Based Genetic Biomarkers Identify Young Boys with Autism Proof-of-principle method suggests much-earlier diagnoses could be done with clinic test 

一針見血測憂鬱:Journal of Clinical Psychiatry上這一篇Commentary A Blood Test for Depression?

………remains unclear is whether the test provides added value for the diagnosis of MDD above and beyond what a trained clinician can do without the test. If the test could provide answers to questions about the patient that are not already known by the trained clinician (eg, predict whether the patient is responding to the treatment before it is clinically noticeable or predict risk in nondepressed patients), then there would be added value for the care and treatment of MDD. Although we are not there yet, hopefully that day is coming soon.

一針見血測失智:台師大(師大光電科技研究所講座教授洪姮娥與副教授謝振傑、廖書賢,和台灣大學醫學院醫師邱銘章、台大物理系教授楊鴻昌、磁量生技公司等人共同組成團隊)領先全球:抽血就可檢測失智症 準確率高達85%

 也來看看A B Niculescu, D Levey, H Le-Niculescu, E Niculescu, S M Kurian and D Salomon等人刊載於 Molecular Psychiatry (2015) 20, 286–288的Psychiatric blood biomarkers: avoiding jumping to premature negative or positive conclusions. Read the rest of this entry »

ERP預測發病的meta-analysis

Forecasting psychosis by event-related potentials — systematic review and specific meta-analysis   Original Research Biological Psychiatry, Available online 1 November 2014, Pages

Mitja Bodatsch, Anke Brockhaus-Dumke, Joachim Klosterkötter, Stephan Ruhrmann

Results

Sensory gating, MMN, and P300 have been demonstrated to be impaired in subjects clinically at risk of developing a psychotic disorder. In the meta-analysis, duration MMN achieved the highest effect size measures.

Conclusions

In summary, MMN studies have produced the most convincing results until now, including independent replication of the predictive validity. However, a synopsis of the literature revealed a relative paucity of ERP studies addressing the psychosis risk state. Considering the high clinical relevance of valid psychosis prediction, future research should question for the most informative paradigms and should allow for meta-analytic evaluation with regard to specificity and sensitivity of the most appropriate parameters.

Keywords

  • Meta-analysis; Mismatch negativity (MMN); P300; Prediction; Prodrome; Psychosis; Sensory gating

2015 Greg Light關於MMN的新文章

Future clinical uses of neurophysiological biomarkers to predict and monitor treatment response for schizophrenia 登載於

Annals of the New York Academy of Sciences  Light GA, Swerdlow NR. 2015 Mar 9. doi: 10.1111/nyas.12730

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2014與2015 土耳其的Eror Basar一系列關於synchronization之文章

Event related desynchronization: use as a neurophysiologic marker is restricted.Cognitive Neurodynamics (Impact Factor: 1.77). 12/2014; 8(6).

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以下13篇,全部出自2015同一期International journal of psychophysiology:這是他的2015個人專輯嗎?!  XD

1. What does the broken brain say to the neuroscientist? Oscillations and Connectivity in Schizophrenia, Alzheimer’s Disease, and Bipolar Disorder. International journal of psychophysiology: official journal of the International Organization of Psychophysiology (Impact Factor: 3.05). 02/2015

2.Multiple gamma oscillations in the brain: a new strategy to differentiate functional correlates and P300 dynamics. International journal of psychophysiology: official journal of the International Organization of Psychophysiology (Impact Factor: 3.05). 02/2015; Read the rest of this entry »

P50與attenuated psychosis syndrome

Sensory gating deficits in the attenuated psychosis syndrome

Imperial College of London研究團隊發表於Schizophrenia Research (Impact Factor: 4.43). 12/2014; 161(2-3).之文章

ABSTRACT Background: Individuals with an “Attenuated Psychosis Syndrome" (APS) have a 20–40% chance of developing a psychotic disorder within two years; however it is difficult to predict which of them will become ill on the basis of their clinical symptoms alone. We examined whether P50 gating deficits could help to discriminate individuals with APS and also those who are particularly likely to make a transition to psychosis. Method: 36 cases meeting PACE (Personal Assessment and Crisis Evaluation) criteria for the APS, all free of anti-psychotics, and 60 controls performed an auditory conditioning–testing experiment while their electroenceph-alogram was recorded. The P50 ratio and its C–T difference were compared between groups. Subjects received follow-up for up to 2 years to determine their clinical outcome. Read the rest of this entry »

Frontal P3a與Glutamine/Glutamate

Harvard Medical School以及Psychosis Neurobiology Laboratory/McLean Hospital的Mei-Hua Hall, 發表於NeuroImage之文章

Frontal P3 Event-Related Potential is related to Brain Glutamine/Glutamate Ratio Measured In Vivo.

ABSTRACT The auditory P3 event-related potential (ERP) is thought to index cognitive processing relevant to attention and working memory processes. Drug challenge studies suggest that glutamate neurotransmission plays an important role in modulating P3 ERP. However, while direct links between glutamate activity and P3 ERP response in humans are suspected, mechanistic details remain largely unknown. We investigated here the relationships between P3 ERP and indices of glutamatergic processing measured in vivo with proton magnetic resonance spectroscopy ((1)H MRS).

We hypothesized that a higher index of glutamatergic processing (Glutamine/Glutamate ratio; abbreviated Gln/Glu) in the anterior cingulate (ACC) and in the parietal-occipital (POC) cortices would associate with larger frontal P3a and parietal P3b amplitudes, respectively. Read the rest of this entry »

思覺失調症的Spontaneous Gamma Activity

哈佛大學Kevin Spencer率領下的  Yoji Hirano日本團隊發表於2015 JAMA Psychiatry的文章Spontaneous Gamma Activity in Schizophrenia.  (Impact Factor: 12.01). 01/2015; DOI: 10.1001/

螢幕快照 2015-10-15 上午11.25.44

ABSTRACT Importance: A major goal of translational neuroscience is to identify neural circuit abnormalities in neuropsychiatric disorders that can be studied in animal models to facilitate the development of new treatments. Oscillations in the gamma band (30-100 Hz) of the electroencephalogram have received considerable interest as the basic mechanisms underlying these oscillations are understood, and gamma abnormalities have been found in schizophrenia (SZ). Animal models of SZ based on hypofunction of the N-methyl-d-aspartate receptor (NMDAR) demonstrate increased spontaneous broadband gamma power, but this phenomenon has not been identified clearly in patients with SZ.

Objective: To examine spontaneous gamma power and its relationship to evoked gamma oscillations in the auditory cortex of patients with SZ. Read the rest of this entry »


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