P50與attenuated psychosis syndrome
Sensory gating deficits in the attenuated psychosis syndrome
Imperial College of London研究團隊發表於Schizophrenia Research (Impact Factor: 4.43). 12/2014; 161(2-3).之文章
ABSTRACT Background: Individuals with an “Attenuated Psychosis Syndrome” (APS) have a 20–40% chance of developing a psychotic disorder within two years; however it is difficult to predict which of them will become ill on the basis of their clinical symptoms alone. We examined whether P50 gating deficits could help to discriminate individuals with APS and also those who are particularly likely to make a transition to psychosis. Method: 36 cases meeting PACE (Personal Assessment and Crisis Evaluation) criteria for the APS, all free of anti-psychotics, and 60 controls performed an auditory conditioning–testing experiment while their electroenceph-alogram was recorded. The P50 ratio and its C–T difference were compared between groups. Subjects received follow-up for up to 2 years to determine their clinical outcome. (繼續閱讀…)