ERP-Lab 台大醫院精神部 神經生理研究室

ERP, MMN, P50, schizophrenia, prodrome, MEG

Archive for the ‘經典綜論’

大腦共振Brain oscillation的分析方法

刊登於2014年5月份的Journal of Neuroscience Methods 228; 15 May 2014, Pages 57–66 之Computational Neuroscience 文章Analytical methods and experimental approaches for electrophysiological studies of brain oscillations


 •Review of methods for studying brain oscillations with MEG/EEG. Covers experimental approaches and analytical methods.

  • Focus on novel experimental approaches such as entrainment.
  • Describes methods for identifying relation between brain oscillations and behaviour.



Steve Luck研究團隊長期致力於ERP研究,ERPLAB的旗艦文獻終於登場了the following paper describing the design and features of ERPLAB:

Lopez-Calderon, J., & Luck, S. J. (2014). ERPLAB: An open-source toolbox for the analysis of event-related potentials. Frontiers in Human Neuroscience, 8, 213. doi: 10.3389/fnhum.2014.00213

ERPLAB Toolbox, which plugs into EEGLAB



 ERPLAB Processing Steps

MMN大老Risto Näätänen兩篇關於MMN的breakthrough文章

2014年,MMN大老芬蘭籍的Risto Näätänen與日本的Yabe發表於International Journal of psychophysiology: official journal of the International Organization of Psychophysiology(IF=3.05)之文章Mismatch negativity (MMN) deficiency: A break-through biomarker in predicting psychosis onset.


The MMN deficit is one of the most robust findings in schizophrenia.

Schizophrenia patients have deficits in the duration MMN in the early course.

Alterations in the MMN at risk-mental state may predict conversion to psychosis.

An important break-through has very recently taken place here in the prediction of conversion to psychosis when the MMN in particular to change in tone duration was recorded in clinically at risk-mental state (ARMS) individuals. Attenuations in the MMN in these patients may be very useful in helping clinicians determine who are most likely to develop a psychotic disorder, as we will review in the present article.

再來看看Näätänen與UCSD的中生代ERP專家Gregory A. Light於2013發表在PNAS之Commentary文章

Mismatch negativity is a breakthrough biomarker for understanding and treating psychotic disorders (繼續閱讀…)

Bipolar disorders跟Schizophrenia的gamma oscillations

土耳其的泰斗Erol Başar刊登於International Journal of Psychophysiology 90 (2013) 99–117之文章

ERP大咖們的最新Review on ERP Biomarkers

1. Neurophysiological Biomarkers Informing the Clinical Neuroscience of Schizophrenia: Mismatch Negativity and Prepulse Inhibition of Startle.Current topics in behavioral neurosciences 05/2014; DOI: 10.1007/7854_2014_316

2.Neuroimaging Biomarkers for Early Drug Development in Schizophrenia.這篇2013年的Biological psychiatry review 有提及2006 GregLight的ASSR

3.A Roadmap for the Development and Validation of Event-Related Potential Biomarkers in Schizophrenia Research Review Article
Biological Psychiatry,  2011;70:28 –34, Available online 15 December 2010
Steven J. Luck, Daniel H. Mathalon, Brian F. O’Donnell, Matti S. Hämäläinen, Kevin M. Spencer, Daniel C. Javitt, Peter J. Uhlhaas

Key Words: Biomarker, ERP, event-related potential, mismatch negativity, P300, schizophrenia









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