ERP-Lab 台大醫院精神部 神經生理研究室

ERP, MMN, P50, schizophrenia, prodrome, MEG

Archive for the ‘最新文章’


Gamma ASSR, 睡眠與 level of arousal

Gamma ASSR會受到睡眠與 level of arousal 的影響

The amplitude and phase precision of 40 Hz auditory steady-state response depend on the level of arousal. 2007 Experimental Brain Research

The 64-channel EEG data was wavelet transformed and the amplitude and phase precision of the wavelet transformed evoked potential were decomposed by the recently proposed multi-subject non-negative multi-way factorization (NMWF) (Morup et al. in J Neurosci Methods 161:361–368, 2007). The estimates of these measures were subjected to statistical analysis. The amplitude and phase precision of the ASSR were significantly larger during the low arousal state compared to the high arousal condition. The modulation of ASSR amplitude and phase precision by differences in the arousal level during recording warrants caution when investigating oscillatory brain activity and interpreting the findings of reduced ASSR in schizophrenia. It also emphasizes the necessity of standardized recording procedures and monitoring the level of arousal during ASSR testing.

40-Hz ASSR fusion classification system for observing sleep patterns. 2015  EURASIP Journal on Bioinformatics and Systems Biology  (繼續閱讀…)

期刊Reviewer參考資源

Bourne PE, Korngreen A (2006) Ten Simple Rules for Reviewers. PLoS Comput Biol 2(9): e110. doi:10.1371/journal.pcbi.0020110. September 29, 2006

Elsevier for Reviewers

2015自閉症的P50 Sensory Gating

2010年之前:『即有一些Autism的P50文章』以下這一些是這幾年更updated的Sensory Gating in Autistic Disorder

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Javitt與Sweet在2015對MMN之新review文章

Auditory dysfunction in schizophrenia: integrating clinical and basic features. Daniel C. Javitt & Robert A. Sweet  Nature Reviews Neuroscience 16, 535–550 (2015)

螢幕快照 2015-10-15 上午11.08.52

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機器學習與藥物療效

A machine learning approach using P300 responses to investigate effect of clozapine therapy. Conf Proc

Engineering in Medicine and Biology Society (EMBC), 2012 Annual International Conference of the IEEE

Clozapine (CLZ) is uniquely effective as a treatment for medication resistant schizophrenia. Information regarding its mechanism of action may offer clues to the pathophysiology of the disease and to improved treatment. In this study we employ a machine learning (ML) analysis of P300 evoked potentials obtained from quantitative electroencephalography (QEEG) data to identify changes in the brain induced by CLZ treatment. (繼續閱讀…)

CFCo與PAC

CFCo= Cross-frequency coupling, The interaction of rhythms in different EEG bands

PAC=Phase-amplitude type Cross Frequency Coupling=Phase-Amplitude-Coupling

Multichannel EEG Signal Recording Analysis based on Cross Frequency Coupling Method.LF Márton et al. Procedia Technology 2014, 12, Pages 133–140

Cross-frequency phase synchronization: A brain mechanism of memory matching and attention. NeuroImage 40 (2008) 308–317

Cross-frequency phase coupling of brain rhythms during the orienting response. BRAIN RESEARCH 1232 (2008) 163 – 172

2015 JuneBiological Psychiatry的Cortical Oscillations特輯

 Cortical Oscillations for Cognitive/Circuit Dysfunction in Psychiatric Disorders Biological Psychiatry 2015; 77(12) Edited by György Buzsáki

  In this IssueA brief summary of the articles appearing in this issue of Biological Psychiatry. Pages 997

Commentary:  Neural Syntax in Mental Disorders    Pages 998-1000 Brendon O. Watson, Gyorgy Buzsaki (繼續閱讀…)

MMN 2015: 7th MMN conference

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 Error Signals from the Brain – 7th Mismatch Negativity Conference (MMN 2015) will be held at the University of Leipzig, Germany, between September 8th and September 11th 2015.

The MMN is an error-signal of the brain that is elicited when an auditory (visual, somato-sensory) stimulus does not match a detected regularity of the sensory environment. It has been used in thousands of experiments in basic and applied (clinical) research to study the brain’s (automatic) encoding and representation of regularities and the detection of respective regularity violations. Therefore the MMN can be regarded as the most influential error signal in cognitive neuroscience. 

The 7th Mismatch Negativity Conference presents the state of the art in methods, theory and application (basic and clinical research) of the MMN. However, it will also cover other error signals of the brain. Moreover, there will be a Hands-on pre-conference workshop devoted to the design of MMN studies and the analysis and interpretation of MMN data as well as a pre-conference workshop on the visual MMN.  (繼續閱讀…)

真會有預測藥物療效的biomarker嗎?

The Promise of Biological Markers for Treatment Response in First-Episode Psychosis: A Systematic ReviewSchizophr Bull (2015)

A rest-activity biomarker to predict response to SSRIs in major depressive disorder. Journal of Psychiatry Research 2015;64

A machine learning approach using EEG data to predict response to SSRI treatment for major depressive disorder.Clinical Neurophysiology 2013 Oct;124(10):1975-85. (繼續閱讀…)

4種MMN均與症狀無關

Judith Ford與Daniel Mathalon研究團隊2015於Biological Psychology的文章Equivalent mismatch negativity deficits across deviant types in early illness schizophrenia-spectrum patients

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