ERP-Lab 台大醫院精神部 神經生理研究室

ERP, MMN, P50, schizophrenia, prodrome, MEG

Archive for the ‘尚未歸類’

MMN: Frequency deviant vs. Duration deviant

本研究室自2009年2月28日起嘗試試用MMN2 paradigm (Both Duration and Frequency MMN are acquired in the same session)      自2010年3月1日起恢復duration MMN paradigm(但兒童個案仍用MMN2 paradigm)

1257~1333; 3261~3335

以下各篇都是同一個研究有做Frequency deviant vs. Duration deviant

  1. MMN responsivity to manipulations of frequency and duration deviants in chronic, clozapine-treated schizophrenia patients Schizophrenia Research, 2010 126(3) Jemeen Horton, Anne Millar, Alain Labelle, Verner J. Knott [Peak latency and amplitude derived from Fz, the site of maximum MMN amplitude]
  2. (繼續閱讀…)

MRS: Glutamate, GABA and Schizophrenia

2011 Schizophrenia Bulletin的新文章Glutamate in Schizophrenia: A Focused Review and Meta-Analysis of 1H-MRS Studies

  1. Medial frontal region glutamate was decreased and glutamine was increased in patients with schizophrenia as compared with healthy individuals.
  2. reflect aberrant processes in schizophrenia, such as altered synaptic activity, changed glutamate receptor functioning, abnormal glutamine-glutamate cycling, or dysfunctional glutamate transport.

同時有fMRI與MRS之文章 2010 Biological Psychiatry 68(7) 625~633 Assessments of Function and Biochemistry of the Anterior Cingulate Cortex in Schizophrenia

  1. abnormal NAA levels, which may reflect a neuronal dysfunction related to schizophrenia, affect neuronal physiology, as evidenced by reduced blood oxygen level–dependent response. (繼續閱讀…)

Time-Frequency Analysis

EEG.PL上對於Time-Frequency Analysis的圖示概念說明

維基百科上的time-frequency analysis


ERSP (繼續閱讀…)

Endophenotypes in schizophrenia




Time lock vs. Phase Lock


Phase locking在Sensory gating之角色:Rosburg T, Trautner P, Fell J, Moxon KA, Elger CE, Boutros NN (2009): Sensory gating in intracranial recordings–the role of phase locking. Neuroimage. 44:1041-1049.


Symptom dimensions of schizophrenia



很多文獻認定PANSS的P-N-G三個總分不夠好:那麼,應當如何看PANSS的Symptom dimensions呢?

話說從頭:1990年,PANSS的作者Stanley Kay在Schizophrenia Bulletin  16(3):537-545上的大作Pyramidical Model of Schizophrenia (繼續閱讀…)


日本東京大學  笠井清登Kiyoto Kasai研究團隊最新力作Preattentive dysfunction in bipolar disorder: A MEG study using auditory mismatch negativity.  Progress in Neuro-Psychopharmacology and Biological Psychiatry 2010

1999 Schizophrenia Research [Impaired sensory processing in male patients with schizophrenia: a magnetoencephalographic study of auditory mismatch detection]

The generation of mismatch negativity (MMN) as a component of auditory evoked event-related brain potentials has been reported previously to be severely disturbed in patients with schizophrenia. In the present study, we extended these findings to magnetoencephalography and investigated the neuromagnetic mismatch field (MMNm) in 15 male schizophrenic inpatients as compared to 16 healthy male volunteers. A standard tone of 1000 Hz and three different types of mismatch (1050-Hz tone, 5000-Hz tone, tone omission) were employed within the same paradigm, each mismatch occurring with a 10% pseudorandom probability. After correction for eye artifacts, the mean global field power of the mismatch reaction was calculated. Mismatch generation in patients with schizophrenia proved to be significantly impaired for all three conditions. This result confirms the theory of impaired auditory information processing in patients with schizophrenia at the level of the primary auditory cortex. Deficient generation of MMNm probably represents an impaired generation and/or faster decay of the sensory memory trace on the basis of disturbed sensory processing in male patients with schizophrenia.

“Cognitive Dysmetria”:Nancy C. Andreasen的精神分裂症大統合理論

Cognitive Dysmetria” as an Integrative Theory of Schizophrenia: A Dysfunction in Cortical-Subcortical-Cerebellar Circuitry?是 Nancy C. Andreasen於1998年在Schizophrenia Bulletin的大作,重點摘要於下 (繼續閱讀…)

P50 vs. Antipsychotics

圖1 (繼續閱讀…)

Facial affect recognition: 與用藥種類無關,也與神心無關?

關於affect recognition:請先看看這一篇潘怡如老師、陳淑惠老師、陳為堅老師、劉絮愷老師的2009年Affect recognition as an independent social function determinant in schizophrenia  Comprehensive Psychiatry, 2009. 50(5): p. 443-52.


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