ERP-Lab 台大醫院精神部 神經生理研究室

ERP, MMN, P50, schizophrenia, prodrome, MEG

Archive for the ‘他山之石’


一針見血早期診斷自閉症  Blood-Based Genetic Biomarkers Identify Young Boys with Autism Proof-of-principle method suggests much-earlier diagnoses could be done with clinic test 

一針見血測憂鬱:Journal of Clinical Psychiatry上這一篇Commentary A Blood Test for Depression?

………remains unclear is whether the test provides added value for the diagnosis of MDD above and beyond what a trained clinician can do without the test. If the test could provide answers to questions about the patient that are not already known by the trained clinician (eg, predict whether the patient is responding to the treatment before it is clinically noticeable or predict risk in nondepressed patients), then there would be added value for the care and treatment of MDD. Although we are not there yet, hopefully that day is coming soon.

一針見血測失智:台師大(師大光電科技研究所講座教授洪姮娥與副教授謝振傑、廖書賢,和台灣大學醫學院醫師邱銘章、台大物理系教授楊鴻昌、磁量生技公司等人共同組成團隊)領先全球:抽血就可檢測失智症 準確率高達85%

 也來看看A B Niculescu, D Levey, H Le-Niculescu, E Niculescu, S M Kurian and D Salomon等人刊載於 Molecular Psychiatry (2015) 20, 286–288的Psychiatric blood biomarkers: avoiding jumping to premature negative or positive conclusions. (繼續閱讀…)

東京大學 笠井清登Kiyoto Kasai研究團隊的NIRS文章

Front Psychiatry. 2013 Nov 14;4:145. doi: 10.3389/fpsyt.2013.00145. eCollection 2013.
Near-infrared spectroscopy in schizophrenia: a possible biomarker for predicting clinical outcome and treatment response.









動物也有Frequency Mismatch Negativity!      Development of a minimally-invasive protocol for recording mismatch negativity (MMN) in the dog (Canis familiaris) using electroencephalography (EEG)    Journal of Neuroscience Methods; 2011, 201(2)  Pages 377–380


► Dog cognition research is based on behaviour, but motivation can affect behaviour. ► An measure of cognitive processing is needed, e.g., mismatch negativity (MMN). ► Animal EEG research has been invasive, but less invasive techniques are promising. ► We present pilot data showing MMN in a dog during an auditory oddball paradigm. ► Potential research includes discrimination tasks, breed differences, development.

螢幕快照 2014-05-02 下午5.19.33




Genetic overlap between ADHD symptoms and EEG theta power Brain and Cognition 2014;87:168~72



qEEG, 憂鬱症與中線電極

Do prefrontal midline electrodes provide unique neurophysiologic information in Major Depressive Disorder?     Journal of Psychiatric Research  2014



Brain oscillatory activity from the midline prefrontal region has been shown to reflect brain dysfunction in subjects with Major Depressive Disorder (MDD). (繼續閱讀…)





(2)EEGLAB處理流程2[52:16] (繼續閱讀…)

Antipsychotics 與anticholinergics 對於HRV之影響

Impact of antipsychotics and anticholinergics on autonomic modulation in patients with schizophrenia.

黃偉烈與郭博昭老師團隊刊登於Journal of clinical Psychopharmacology 2013 Apr;33(2):170-7的大作 (繼續閱讀…)

Steve Luck對於ERP實驗設計的『十誡』

看看UC Davis的Steve Luck聖經中第貳章,對於ERP實驗設計的『十誡』吧

Ten Simple Rules for Designing ERP experiments

Page 30: Number of Trials and SNR

ERPLAB的教學Videos (繼續閱讀…)

Dysconnectivity between frontal/thalamus/amygdala

這一篇臺北榮總,陽明林慶波教授團隊與北京Tianzi Jiang教授團隊刊登於Schizophrenia Research的文章,強調了Schizophrenia的dysconnectivity      Disrupted thalamo-cortical connectivity in schizophrenia: A morphometric correlation analysis

Topography of connections between human prefrontal cortex and mediodorsal thalamus studied with diffusion tractography. Neuroimage. 2010 June; 51(2): 555–564.

Altered resting-state functional connectivity of thalamus in earthquake-induced posttraumatic stress disorder: a functional magnetic resonance imaging study. Brain Research 2011 Sep 9;1411:98-107.鞏啟勇團隊

Functional connectivity between ventral prefrontal cortex and amygdala at low frequency in the resting state in bipolar disorder.Psychiatry Research 2010 Jun 30;182(3):207-10. Epub 2010 May 20.


師大大腦科學應用中心下、腦磁造影實驗室MEG的製造廠商 KRISS韓國國家標準及科學研究院Korea Research Institute of Standards and Science

這一篇Enhancing Accuracy in Magneto- and Electroencephalography Focal Source Localization是他們所寫的IEEE TRANSACTIONS ON MAGNETICS, VOL. 42, NO. 4, APRIL 2006

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