ERP-Lab 台大醫院精神部 神經生理研究室

ERP, MMN, P50, schizophrenia, prodrome, MEG

Archive for the ‘一方之霸’

思覺失調症的graph theory研究

基礎閱讀World J Psychiatr 2012 February 22; 2(1): 1-12  Graph-based network analysis in schizophrenia

Key words: Schizophrenia; Graph theory; Small world networks; Brain networks; Brain connectivity

陽明大學林慶波教授團隊2015 於PNAS所發表的Randomization and resilience of brain functional networks as systems-level endophenotypes of schizophrenia Chun-Yi Zac Lo, Tsung-Wei Su, Chu-Chung Huang, Chia-Chun Hung, Wei-Ling Chen, Tsuo-Hung Lan, Ching-Po Lin and Edward T. Bullmore (繼續閱讀…)


Auditory dysfunction in schizophrenia: integrating clinical and basic features. Daniel C. Javitt & Robert A. Sweet  Nature Reviews Neuroscience 16, 535–550 (2015)

螢幕快照 2015-10-15 上午11.08.52


Brain’s alpha, beta, gamma, delta, and theta oscillations in neuropsychiatric diseases

Brain’s alpha, beta, gamma, delta, and theta oscillations in neuropsychiatric diseases: Proposal for biomarker strategies. 土耳其的泰斗Basar刊登於Supplements to Clinical neurophysiology 01/2013的文章

螢幕快照 2015-06-04 下午7.54.02


2014與2015 土耳其的Eror Basar一系列關於synchronization之文章

Event related desynchronization: use as a neurophysiologic marker is restricted.Cognitive Neurodynamics (Impact Factor: 1.77). 12/2014; 8(6).


以下13篇,全部出自2015同一期International journal of psychophysiology:這是他的2015個人專輯嗎?!  XD

1. What does the broken brain say to the neuroscientist? Oscillations and Connectivity in Schizophrenia, Alzheimer’s Disease, and Bipolar Disorder. International journal of psychophysiology: official journal of the International Organization of Psychophysiology (Impact Factor: 3.05). 02/2015

2.Multiple gamma oscillations in the brain: a new strategy to differentiate functional correlates and P300 dynamics. International journal of psychophysiology: official journal of the International Organization of Psychophysiology (Impact Factor: 3.05). 02/2015; (繼續閱讀…)

思覺失調症的Spontaneous Gamma Activity

哈佛大學Kevin Spencer率領下的  Yoji Hirano日本團隊發表於2015 JAMA Psychiatry的文章Spontaneous Gamma Activity in Schizophrenia.  (Impact Factor: 12.01). 01/2015; DOI: 10.1001/

螢幕快照 2015-10-15 上午11.25.44

ABSTRACT Importance: A major goal of translational neuroscience is to identify neural circuit abnormalities in neuropsychiatric disorders that can be studied in animal models to facilitate the development of new treatments. Oscillations in the gamma band (30-100 Hz) of the electroencephalogram have received considerable interest as the basic mechanisms underlying these oscillations are understood, and gamma abnormalities have been found in schizophrenia (SZ). Animal models of SZ based on hypofunction of the N-methyl-d-aspartate receptor (NMDAR) demonstrate increased spontaneous broadband gamma power, but this phenomenon has not been identified clearly in patients with SZ.

Objective: To examine spontaneous gamma power and its relationship to evoked gamma oscillations in the auditory cortex of patients with SZ. (繼續閱讀…)

EEG Biomarkers of Psychosis, Present and Future

UCSD的EEG/ERP expert Gregory A.Light與SCCN的大老 Scott Makeig,針對在Biological Psychiatry 刊登的B-SNIP文章”Ethridge LE, Hamm JP, Pearlson GD, Tamminga CA, Sweeney JA, Keshavan MS,Brett A. Clementz(2015): Event related potential and time-frequency endophenotypes for schizophrenia and psychotic bipolar disorder. ”

於同期Biological Psychiatry所進行之Commentary:  EEG Biomarkers of Psychosis, Present and Future (繼續閱讀…)

Garrido與Friston團隊對於neuronal mechanisms underlying the MMN generation之卓見

位於Wellcome Trust Centre for Neuroimaging, University College London, United Kingdom的MI Garrido 與Karl Friston所出版的 The mismatch negativity: A review of underlying mechanisms      Clinical Neurophysiology Volume 120, Issue 3, March 2009, Pages 453-463


MMN generators estimated from EEG and MEG data. The centre of gravity changes from temporal to frontal areas over time. Frontal sources were detected with EEG; due to their radial orientation they might not be detected by MEG. These sources were determined with minimum norm estimates (MNE). (Adapted from Rinne et al., 2000.) (繼續閱讀…)

N-acetylcysteine, NMDA, MMN與P300

Daniel Mathalon與 Judith Ford研究團隊刊登在2012 Biological Psychiatry 71(11):969-77.的文章 Glutamatergic modulation of auditory information processing in the human brain

MATLAB Handle Graphics (繼續閱讀…)


Steve Luck研究團隊長期致力於ERP研究,ERPLAB的旗艦文獻終於登場了the following paper describing the design and features of ERPLAB:

Lopez-Calderon, J., & Luck, S. J. (2014). ERPLAB: An open-source toolbox for the analysis of event-related potentials. Frontiers in Human Neuroscience, 8, 213. doi: 10.3389/fnhum.2014.00213

ERPLAB Toolbox, which plugs into EEGLAB



 ERPLAB Processing Steps

Steve Luck 關於到底要不要用average reference的高見

到底要不要用average reference? 以下是Steve Luck的寶貴建議

As discussed in chapter 3 of my book on ERP methods (An Introduction to the Event-Related Potential Technique), there is no such thing as a perfect reference.  You are always looking at the potential (difference) between one site and another site (or set of sites).  The reference site (or sites) will have a substantial effect on the waveforms.  The only exception to this is when you use the average of the entire head as the reference (because the average across the entire head necessarily sums to zero).  You can approximate this with very large sets of electrodes (see Dien, 1998), but most people who use the average of all electrodes do not cover enough of the head to achieve a very good approximation.  Transforming to current source density is another good approach, but it also requires a large set of electrodes to work well. (繼續閱讀…)

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