Javitt與Sweet在2015對MMN之新review文章
Auditory dysfunction in schizophrenia: integrating clinical and basic features. Daniel C. Javitt & Robert A. Sweet Nature Reviews Neuroscience 16, 535–550 (2015)
Mismatch negativity(MMN). A component of an event-related potential that reflects NMDA receptor-mediated information processing within the auditory sensory cortex, permitting its use as a translational biomarker of NMDA receptor dysfunction in schizophrenia research.
Gating. The reduction in the amplitude of the response to a second stimulus compared with amplitude to the first stimulus in a paired auditory stimulus.
Ketamine A well-studied non-competitive NMDA receptor antagonist that induces transient schizophrenia-like symptoms in healthy human volunteers and schizophrenia-like event-related potential abnormalities in non-human primates.
Abstract | Schizophrenia is a complex neuropsychiatric disorder that is associated with persistent psychosocial disability in affected individuals. Although studies of schizophrenia have traditionally focused on deficits in higher-order processes such as working memory and executive function, there is an increasing realization that, in this disorder, deficits can be found throughout the cortex and are manifest even at the level of early sensory processing. These deficits are highly amenable to translational investigation and represent potential novel targets for clinical intervention. Deficits, moreover, have been linked to specific structural abnormalities in post-mortem auditory cortex tissue from individuals with schizophrenia, providing unique insights into underlying pathophysiological mechanisms.
